Interactions Ĭalcium forms complexes with a number of pharmaceutical drugs, reducing their bioavailability among them are tetracyclines, quinolone antibiotics, levothyroxine, and bisphosphonates, as well as iron, magnesium and zinc supplements. Extreme or long-term or overdose can theoretically result in hypervitaminosis D, kidney stones, chronic kidney disease, and calcinosis. If very high doses are taken, signs of hypercalcaemia (abnormally high blood calcium levels) have been described, such as stomach pain, vomiting, thirst, and tiredness. Possible side effects include gastrointestinal problems, for example nausea and constipation. In 2020, the combination, calcium/vitamin D was the 215th most commonly prescribed medication in the United States, with more than 2 million prescriptions. It is used to prevent and treat lack of calcium and vitamin D in the elderly, as well for osteoporosis in combination with other medications. Calcium/cholecalciferol is a combination of a calcium salt (usually calcium carbonate) and vitamin D 3 (cholecalciferol).
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